Celiac disease and obstetrical-gynecological contribution

Celiac disease [CD] shows an increased prevalence in female, particularly during the fertile period. Celiac diseaseshould be researched in infertility, spontaneous and recurrent abortions, delayed menarche, amenorrhea, earlymenopause, and children with low birth-weight. Celiac disease is still little considered during the evaluation ofinfertility. Up to 50% of women with untreated CD refer an experience of miscarriage or an unfavorable outcome ofpregnancy. Celiac patients taking a normal diet [with gluten] have a shorter reproductive period. Women withundiagnosed CD had a higher risk of small for gestation age infants very small for gestational age infants and pretermbirth when compared with women with noted CD. The link between NCGS and infertility is actually unknown.The goal of our work is to perform an actual review about this topic and to increase the awareness in the medical population to research celiac disease in selected obstetric and gynecological disorders

Gastrointestinal and non-gastrointestinal presentation in patients with celiac disease

Celiac disease [CD] may have a variety of different presentations. This study has aimed to explore the prevalence of gastrointestinal [GI] and non-GI symptoms in patients with CD according to data collected in Italy and Romania [Europe] and Iran [Middle East]. This is a retrospective cross-sectional study conducted in Iran, Romania and Italy with data collection during the period from May 2009 - May 2011. For each center we included only patients with CD that was confirmed by endoscopy, small bowel biopsies and positive serology. GI symptoms such as abdominal pain, diarrhea, constipation, nausea and vomiting, weight loss and flatulence, as well as additional signs and symptoms of iron deficiency anemia [IDA], osteoporosis, hypertransaminasemia, and other related abnormalities were collected. Overall, 323 women and 127 men, whose mean age at diagnosis was 34.2 +/- 16.47 years were included in this study. Of these, 157 subjects [34.9%] reported at least one GI symptom. The majority of cases had the following primary presenting GI symptoms: diarrhea [13.6%], dyspepsia and constipation [4.0%]. Other disease symptoms were reported by 168 [37.3%] patients. The most presenting non-GI symptoms in the majority of cases were anemia [20.7%] and osteopenia [6%]. There were statistically significant differences between the majority of symptoms when we compared the reported clinical symptoms from different countries. This study indicated that upper abdominal disorders such as abdominal pain and dyspepsia were the most common primary complaints among European patients, whereas Iranian patients had complaints of diarrhea and bloating as the classic presentations of CD. For non-GI symptoms, anemia was the most frequent complaint for both Iranian and Italian patients; however it was significantly higher in Iranians

Papillary thyroid cancer and ulcerative colitis

Ulcerative colitis is associated with several malignancies. Here we report one such association, a rare one, with papillary thyroid carcinoma, and discuss the possible risk factors of such an association